Article
Molecular Landscape of BRAF-Mutant NSCLC Reveals an Association Between Clonality and Driver Mutations and Identifies Targetable Non-V600 Driver Mutations.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Oct 2020
Negrao Marcelo V, Raymond Victoria M, Lanman Richard B, Robichaux Jacqulyne P, He Junqin, Nilsson Monique B, Ng Patrick K S, Amador Bianca E, Roarty Emily B, Nagy Rebecca J, Banks Kimberly C, Zhu Viola W, Ng Chun, Chae Young Kwang, Clarke Jeffrey M, Crawford Jeffrey A, Meric-Bernstam Funda, Ignatius Ou Sai-Hong, Gandara David R, Heymach John V, Bivona Trever G, McCoach Caroline E
Abstract excerpt
INTRODUCTION: Approximately 4% of NSCLC harbor BRAF mutations, and approximately 50% of these are non-V600 mutations. Treatment of tumors harboring non-V600 mutations is challenging because of functional heterogeneity and lack of knowledge regarding their clinical significance and response to targeted agents. METHODS: We conducted an integrative analysis of BRAF non-V600 mutations using genomic profiles of...
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