Impact of BRAF Mutation Class on Disease Characteristics and Clinical Outcomes in BRAF-mutant Lung Cancer

Abstract excerpt

Abstract Purpose: BRAF mutations are divided into functional classes distinguished by signaling mechanism and kinase activity: V600-mutant kinase-activating monomers (class I), kinase-activating dimers (class II), and kinase-inactivating heterodimers (class III). The relationship between functional class and disease characteristics in BRAF-mutant non–small cell lung cancer (NSCLC) has not been fully explored....

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• Lung Cancer Diagnosis and Treatment
• Lung Cancer Treatments and Mutations
• Melanoma and MAPK Pathways