Article
[Progress of BRAF Gene Alteration in Non-small Cell Lung Cancer].
Zhongguo fei ai za zhi = Chinese journal of lung cancer - 20 Jan 2024
Deng Libian, Yang Yaxian, Huang Jian
Abstract excerpt
V-Raf murine sarcoma viral oncogene homolog B (BRAF) alteration is one of the most essential driver genes of non-small cell lung cancer (NSCLC). BRAF encodes serine/threonine protein kinases, and its mutations typically lead to protein compositional activation, thereby activating the mitogen-activated protein kinase kinase (MEK) signaling pathway. A promising new approach for the treatment of mutated BRAF and/or...
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