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Article

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers.

Annals of clinical and translational neurology - 1 Jun 2026

Buyukkurt Asli, Ygonia Marius, Manouchehrinia Ali, Lefrançois Philippe, Kockum Ingrid, Harroud Adil

Abstract excerpt

OBJECTIVE: Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease-modifying therapies may contribute to this variability. This study aimed to assess the potential causal effects and shared genetic risk between MS and 12 common cancers. METHODS: We used large-scale genetic studies for MS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41540890
DOI: 10.1002/acn3.70298
PMCID: PMC13251448

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BACH2

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