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Article

Unveiling cholesterol metabolism-related gene ACOX2: a multi-omics discovery of a novel biomarker in IgA nephropathy.

Hereditas - 15 Jan 2026

Deng Xiaoqi, Wu Jinlan, He Mengxi, Mei Lin, Ma Li, Lin Yun, Luo Yu

Abstract excerpt

BACKGROUND: The role of cholesterol metabolism in IgA nephropathy (IgAN) remains poorly understood. METHODS: We applied a multi-omics integrative framework to systematically identify key regulatory genes. This approach combined genome-wide association study (GWAS), summary-data-based mendelian randomization (SMR), conventional MR, Bayesian colocalization, single-cell RNA sequencing (scRNA-seq), bulk transcriptome...

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Source

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Identifiers

PMID: 41540492
DOI: 10.1186/s41065-026-00639-0
PMCID: PMC12888180

Genes

ACOX2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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