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Article

Mucinous Adenocarcinoma With Intrapulmonary Metastasis Harboring KRAS and GNAS Mutations Arising in Congenital Pulmonary Airway Malformation.

American journal of clinical pathology - 6 Jul 2021

de Cordova Ximena Fernandez, Wang Huiying, Mehrad Mitra, Eisenberg Rosana, Johnson Joyce, Wei Qiang, Borinstein Scott, Danko Melissa E, Liang Jiancong

Abstract excerpt

OBJECTIVES: Mucinous adenocarcinoma arising in unresected congenital pulmonary airway malformation (CPAM) is rare. Underlying driver mutations in addition to KRAS gain-of-function mutations in this setting and the long-term outcomes of these patients are unknown. METHODS: We report a case of metastatic mucinous adenocarcinoma harboring both KRAS and GNAS mutations arising in a type 1 CPAM of a 14-year-old male. A...

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PMID: 33609098
DOI: 10.1093/ajcp/aqaa245

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