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Article

Defining the spatial landscape of KRAS mutated congenital pulmonary airway malformations: a distinct entity with a spectrum of histopathologic features.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2022

Nelson Nya D, Xu Feng, Chandrasekaran Prashant, Litzky Leslie A, Peranteau William H, Frank David B, Li Marilyn, Pogoriler Jennifer

Abstract excerpt

The potential pathogenetic mechanisms underlying the varied morphology of congenital pulmonary airway malformations (CPAMs) have not been molecularly determined, but a subset have been shown to contain clusters of mucinous cells (MCC). These clusters are believed to serve as precursors for potential invasive mucinous adenocarcinoma, and they are associated with KRAS codon 12 mutations. To assess the universality...

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Identifiers

PMID: 35794233
DOI: 10.1038/s41379-022-01129-0
PMCID: PMC10462420

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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