Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of TNF-α (- 308G>A and - 857 C>T) promoter variants on susceptibility to chronic hepatitis B virus infection in a cohort of Mauritanian patients: pilot study.

BMC microbiology - 15 Jan 2026

Ennahoui Saffiya Mounira, M'Hamed Abdallah Sid, Veten Fatimetou, Cheikh Bouna Sidi M, Barakat Abdelhamid, Soumbara Tetou, Houmeida Ahmed

Abstract excerpt

BACKGROUND: Genetic polymorphisms within the tumor necrosis factor (TNF) cluster have been implicated in several diseases. This exploratory study aimed to assess the role of two polymorphisms (− 308G > A and − 857 C > T) in the TNF-α gene in the risk of developing chronic Hepatitis B virus (CHB) infection in a cohort of Mauritanian patients. METHODS: We selected 160 subjects, including 82 patients with CHB and 78...

Topics

Join the communities discussing this publication.

Cohort Studies
Gene Frequency
Hepatitis B, Chronic
Hepatitis B virus
Pilot Projects

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Promoter Regions, Genetic

Tumor Necrosis Factor-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 41540347
DOI: 10.1186/s12866-026-04714-4
PMCID: PMC12947466

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of TNF-α (- 308G>A and - 857 C>T) promoter variants on susceptibility to chronic hepatitis B virus infection in a cohort of Mauritanian patients: pilot study.PMID 41540347Read ↗

Association of TNF-Alpha gene polymorphisms and susceptibility to hepatitis B virus infection in Egyptians.Semantic proximity Read ↗

Tumour necrosis factor-α-857T allele reduces the risk of hepatitis B virus infection in an Asian population.Semantic proximity Read ↗

Tumor necrosis factor-alpha-308A allele may have a protective effect for chronic hepatitis B virus infection in Mongoloid populations.Semantic proximity Read ↗

[Association of TNF-α-308 polymorphisms with risk of chronic HBV infection in the Chinese population: a meta-analysis].Semantic proximity Read ↗

The relationship between tumour necrosis factor-α gene polymorphism and susceptibility and clearance of the persistent hepatitis B virus infection in a Chinese population: a meta-analysis.Semantic proximity Read ↗

The tumour necrosis factor-α-238A allele increases the risk of chronic HBV infection in European populations.Semantic proximity Read ↗

Association of TNF-α Gene Polymorphisms with Production of Protein and Susceptibility to Chronic Hepatitis B Infection in the South East Iranian PopulationSemantic proximity Read ↗

Relationship between TNF-<alpha> gene promoter polymorphisms and outcomes of hepatitis B virus infections: a meta-analysis.Semantic proximity Read ↗

Tumor necrosis factor-alpha gene promoter polymorphism in Iranian patients with chronic hepatitis B.Semantic proximity Read ↗

Tumor Necrosis Factor Alpha 308 G/A Single Nucleotide Polymorphism and Susceptibility to Hepatocellular Carcinoma Via Hepatitis B Infection.Semantic proximity Read ↗

TNF-alpha promoter region polymorphisms affect HBV virus clearance in southern Chinese.Semantic proximity Read ↗

The relationship between TNF alpha gene polymorphisms (-238/-308), TNF RII VNTR (p75) and outcomes of hepatitis B virus infection in Tunisian population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.