Article
In situ visualization of Clostridioides difficile phenotypic heterogeneity and single-cell morphology during gut infection.
Nature communications - 14 Jan 2026
DiBenedetto Nicholas V, Donnelly-Morell M Lauren, Kumamoto Carol A, Shen Aimee
Abstract excerpt
Phenotypic heterogeneity refers to the ability of clonal populations of the same species to display distinct phenotypes despite experiencing the same environment. Bacteria exhibit phenotypic heterogeneity across diverse cellular processes, which can provide competitive fitness advantages both within the host and against surrounding microbiota. However, visualizing phenotypic heterogeneity at single-cell...
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