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Brain functional abnormalities: a bridge between insulin signaling pathway gene polymorphisms and clinical cognition in early-onset obsessive-compulsive disorder.

European child & adolescent psychiatry - 1 May 2026

Ding Hui, Shi Xu, Xie Minyao, Zhang Xuedi, Liu Na

Abstract excerpt

OBJECTIVE: Obsessive-compulsive disorder (OCD) is a neurodevelopmental disorder, related to the central insulin signaling pathway. We investigate the relationship among central insulin signaling pathway gene polymorphisms/brain functional and clinical features in early-onset OCD(EO-OCD). METHODS: Candidate single nucleotide polymorphisms(SNPs) were genotyped and functional magnetic resonance imaging (FMRI) was...

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PMID: 41533078
DOI: 10.1007/s00787-025-02958-5

Genes

RACGAP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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