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Article

Mendelian Randomization Study Supports Genetic Liability to Obsessive-Compulsive Disorder Associated With the Risk of Alzheimer's Disease.

Brain and behavior - 1 Oct 2024

Cao Si, Su Han, Zhang Xiaoyi, Fang Chao, Wu Nayiyuan, Zeng Youjie, Chen Minghua

Abstract excerpt

BACKGROUND: Observational studies have suggested that obsessive-compulsive disorder (OCD) may be associated with Alzheimer's disease (AD). However, whether OCD is a causal risk factor for AD remains unclear. This study aimed to assess the causal effect of OCD on AD risk by performing a two-sample Mendelian randomization (MR) analysis. METHODS: Genome-wide association summary statistics were obtained for OCD,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39344387
DOI: 10.1002/brb3.70081
PMCID: PMC11440019

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