Article
Influence of lifestyle and genetic variants in the aldo-keto reductase 1C3 rs12529 polymorphism in high-risk prostate cancer detection variability assessed between US and New Zealand cohorts.
PloS one - 1 Jan 2018
Karunasinghe Nishi, Ambs Stefan, Wang Alice, Tang Wei, Zhu Shuotun, Dorsey Tiffany H, Goudie Megan, Masters Jonathan G, Ferguson Lynnette R
Abstract excerpt
INTRODUCTION: The prostate-specific antigen (PSA) based prostate cancer (PC) screening is currently being debated. The current assessment is to understand the variability of detecting high-risk PC in a NZ cohort in comparison to a US cohort with better PSA screening facilities. Aldo-keto reductase 1C3 (AKR1C3) is known for multiple functions with a potential to regulate subsequent PSA levels. Therefore, we wish...
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