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Article

Cadmium-induced activation of inflammatory cancer-associated fibroblasts-like cells enhances malignant phenotypes of lung cancer cells.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Apr 2026

Jiang Qi, Wang Lujiao, Chen Biyun, Dong Tianyi, Shen Wanyou, Zhou Xue

Abstract excerpt

Cancer-associated fibroblasts (CAFs), as key stromal components of the tumor microenvironment (TME), exert profound influences on tumor progression by secreting cytokines, exosomes, and remodeling the extracellular matrix (ECM). Cadmium (Cd), a hazardous heavy metal, is strongly associated with lung carcinogenesis through environmental and occupational exposure. However, the molecular mechanisms underlying...

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Identifiers

PMID: 41519222
DOI: 10.1016/j.fct.2026.115927

Genes

FAP
CCL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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