Article
The pathogenesis of obesity from a genomic and systems biology perspective.
The Yale journal of biology and medicine - 1 Jun 2014
Levian Candace, Ruiz Esmeralda, Yang Xia
Abstract excerpt
The recent obesity epidemic has imposed significant health, economical, and societal concerns. However, effective preventive and therapeutic strategies are currently lacking, primarily due to a lack of comprehensive understanding of the underlying molecular mechanisms. Recent genome-wide scans of genetic variants, transcriptome, and epigenome have uncovered >50 genetic loci that predispose individuals to obesity...
Topics
- Environment
- Genetic Predisposition to Disease
- Genomics
- Humans
- Obesity
- Risk Factors
- Systems Biology