Interactive Effects of Genetic Susceptibility and Early-Life Tobacco Smoke Exposure on the Asthma-Eczema Complex Phenotype in Children: 6-Year Follow-Up Case-Control Study.

Abstract excerpt

Atopic eczema and asthma frequently co-occur, forming a distinct complex phenotype that likely arises from shared genetic pathways and early-life environmental influences. We aimed to investigate whether variants in TNS1 and NRXN1-previously identified in a genome-wide interaction study-influence susceptibility to atopic eczema and the asthma-eczema phenotype and whether early-life environmental tobacco smoke...

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