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Article

Mutation of glutamate 155 of the GABAA receptor beta2 subunit produces a spontaneously open channel: a trigger for channel activation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Dec 2004

Newell J Glen, McDevitt Ross A, Czajkowski Cynthia

Abstract excerpt

Protein movements underlying ligand-gated ion channel activation are poorly understood. The binding of agonist initiates a series of conformational movements that ultimately lead to the opening of the ion channel pore. Although little is known about local movements within the GABA-binding site, a...

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Identifiers

PMID: 15601928
DOI: 10.1523/JNEUROSCI.3746-04.2004
PMCID: PMC6730373

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15601928-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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