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Emerging Understanding of Multiscale Tumor Heterogeneity

18 Dec 2014

Abstract excerpt

Cancer is a multifaceted disease characterized by heterogeneous genetic alterations and cellular metabolism, at the organ, tissue, and cellular level. Key features of cancer heterogeneity are summarized by 10 acquired capabilities, which govern malignant transformation and progression of invasive tumors. The relative contribution of these hallmark features to the disease process varies between cancers. At the DNA...

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PMID: 25566504
DOI: 10.3389/fonc.2014.00366

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