Genomes and epigenomes of matched normal and tumor breast tissue reveal diverse evolutionary trajectories and tumor-host interactions.

doi:10.1016/j.ajhg.2024.10.005

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Article

Genomes and epigenomes of matched normal and tumor breast tissue reveal diverse evolutionary trajectories and tumor-host interactions.

American journal of human genetics - 5 Dec 2024

Zhu Bin, Tapinos Avraam, Koka Hela, Yi Lee Priscilla Ming, Zhang Tongwu, Zhu Wei, Wang Xiaoyu, Klein Alyssa, Lee DongHyuk, Tse Gary M, Tsang Koon-Ho, Wu Cherry, Hua Min, Highfill Chad A, Lenz Petra, Zhou Weiyin, Wang Difei, Luo Wen, Jones Kristine, Hutchinson Amy, Hicks Belynda, Garcia-Closas Montserrat, Chanock Stephen, Tse Lap Ah, Wedge David C, Yang Xiaohong R

Abstract excerpt

Normal tissues adjacent to the tumor (NATs) may harbor early breast carcinogenesis events driven by field cancerization. Although previous studies have characterized copy-number (CN) and transcriptomic alterations, the evolutionary history of NATs in breast cancer (BC) remains poorly characterized. Utilizing whole-genome sequencing (WGS), methylation profiling, and RNA sequencing (RNA-seq), we analyzed paired...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39492056
DOI: 10.1016/j.ajhg.2024.10.005
PMCID: PMC11639081

Genes

AKT1
CD14
GATA3
PIK3CA
TP53

Provenance

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