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Article

Postpartum breast cancer: evidence for a distinct phenotype.

Journal of the National Cancer Institute - 1 May 2026

Sherman Mark E, Etievant Lola, Vierkant Robert A, Winham Stacey J, Ruddy Kathryn J, Pacheco-Spann Laura, Wickland Daniel P, Cruz-Reyes Nicole, Stallings-Mann Melody, Radisky Derek, Thompson E Aubrey, Kachergus Jennifer M, Shi Ji, Rosenberg Shoshana M, Snow Craig, Kirkner Gregory J, Schapira Lidia, Peppercorn Jeffrey M, Come Steven, Borges Virginia F, Warner Ellen, Collins Laura C, Partridge Ann H, Pfeiffer Ruth M

Abstract excerpt

BACKGROUND: The incidence of early onset breast cancers (BCs) has increased, paralleling rising trends in delayed childbearing. We hypothesize that a distinct postpartum BC (PPBC) subtype, identifiable by time since last birth (TSLB) and biomarker expression, contributes to this trend. METHODS: We applied GeoMx Digital Spatial Profiling (DSP) to measure associations between TSLB and 71 proteins in 640 BCs from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41512289
DOI: 10.1093/jnci/djag003
PMCID: PMC13155230

Genes

PTEN
CTLA4
DSP
GZMB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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