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Article

Antecedent enhancer activity predicts future susceptibility to seizures in mice.

Nature communications - 8 Jan 2026

Boros Benjamin D, Gachechiladze Mariam A, Guo Juanru, Galloway Dylan A, Mueller Shayna M, Shabsovich Mark, Yen Allen, Chen Xuhua, Cammack Alexander J, Shen Tao, Mitra Robi D, Dougherty Joseph D, Miller Timothy M

Abstract excerpt

Wide variation of responses to identical stimuli presented to genetically inbred mice suggests the hypothesis that stochastic non-genetic variation, such as in chromatin state or enhancer activity during neurodevelopment, can mediate such phenotypic differences. However, this hypothesis is largely untested since capturing pre-existing molecular states requires non-destructive, longitudinal recording. Therefore,...

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Share to Disease Models, Animal
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Mice, Inbred C57BL

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Share to Phenotype

Share to Seizures

Source

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Identifiers

PMID: 41507153
DOI: 10.1038/s41467-025-65346-2
PMCID: PMC12789462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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