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Potential synergistic role of pre-formed GSTT1 antibodies and de novo HLA antibodies in a heart-transplant recipient diagnosed with AMR.

Human immunology - 1 Feb 2026

Chitnis Nilesh S, Nunugonda Maanika, Foye Catherine, Erice Phillip A, Robinson Philip J, Cortes-Santiago Nahir, Kearney Debra L, Spinner Joseph A, Jindra Peter T

Abstract excerpt

Our center had a case of a 20-year old female with severe bi-ventricular dysfunction, leading to heart transplantation. Strong GSTT1 antibody was detected pre-transplant, which encouraged us to further study its possible significance. Glutathione S-transferases (GSTs) are a class of enzymes that metabolize xenobiotics. We hypothesized that high-titer non-HLA antibodies to GSTT1 can be generated in recipients who...

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Identifiers

PMID: 41506028
DOI: 10.1016/j.humimm.2025.111648

Genes

GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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