Article
Alloimmune response against donor glutathione S-transferase T1 antigen in renal transplant recipients.
American journal of kidney diseases : the official journal of the National Kidney Foundation - 1 Aug 2005
Aguilera Isabel, Wichmann Ingeborg, Gentil Miguel Angel, Gonzalez-Escribano Francisca, Nuñez-Roldan Antonio
Abstract excerpt
BACKGROUND: The long-term outcome of kidney transplantation could be influenced by the appearance of antibodies against donor-specific antigens. Glutathione S-transferase T1 (GSTT1) is a protein preferentially expressed in liver and kidney cells. Deletion of the GSTT1 gene results in a complete lack of protein expression, which occurs in 20% of the white population. GSTT1 donor-recipient mismatch has been...
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