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Article

CYP2D6 Phenotype as a Predictor of Adverse Drug Reactions in Patients Treated With Trazodone: An Explorative Pharmacogenetic Study.

Journal of clinical psychopharmacology - 1 Jan 2026

Wiss Florine M, Krieg Christian D, Lampert Markus L, Meyer Zu Schwabedissen Henriette E, Stäuble Céline K, Mikoteit Thorsten, Imboden Christian, Allemann Samuel S

Abstract excerpt

PURPOSE: Trazodone is metabolized by CYP3A4 to the active metabolite meta-chlorophenylpiperazine (mCPP), which is associated with various adverse drug reactions (ADRs). mCPP is further inactivated by CYP2D6. Despite the knowledge of trazodone metabolism, the evidence regarding the impact of pharmacogenetics remains limited. This study aimed to examine the association between pharmacogenetic variants in genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41496526
DOI: 10.1097/JCP.0000000000002123
PMCID: PMC12931868

Genes

CYP3A5
ABCB1
CYP3A4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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