Article
Cyp2d6*3, *4, *5 and *6 polymorphisms and antipsychotic-induced extrapyramidal side-effects in patients receiving antipsychotic therapy.
Clinical and experimental pharmacology & physiology - 1 Jul 2008
Crescenti Anna, Mas Sergi, Gassó Patricia, Parellada Eduard, Bernardo Miquel, Lafuente Amalia
Abstract excerpt
1. The aim of the present study was to examine the relationship between CYP2D6 polymorphisms and the risk of antipsychotic (AP)-induced extrapyramidal symptoms (EPS) in patients receiving AP treatment. The allele status for CYP2D6*3, CYP2D6*4, CYP2D6*5 and CYP2D6*6 was determined in 267 patients receiving AP therapy. Seventy-nine cases presenting with EPS (Simpson-Angus Scale 3) and 188 controls without EPS...
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