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Article

Influence of CYP2D6 Genotypes and Phenotypes on the Plasma Levels and Clinical Response to Aripiprazole.

Schizophrenia bulletin - 7 Mar 2026

Gras Cécile, Piras Marianna, Ranjbar Setareh, Grosu Claire, Girardin François R, Vandenberghe Frederik, Ansermot Nicolas, Grandjean Carole, Kaiser Stefan, Gamma Franziska, Plessen Kerstin Jessica, von Gunten Armin, Conus Philippe, Crettol Séverine, Eap Chin B

Abstract excerpt

BACKGROUND: The antipsychotic aripiprazole is mainly metabolized by the cytochrome P450 (CYP) 2D6. The main objective of this study was to evaluate the influence of CYP2D6 phenotypes on aripiprazole plasma levels and treatment duration. DESIGN: 466 patients treated with aripiprazole for up to 12 months and with at least one aripiprazole plasma level in steady-state condition were selected. CYP2D6 genotypes and...

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Identifiers

PMID: 40662264
DOI: 10.1093/schbul/sbaf076
PMCID: PMC12996889

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