Article
Association of interleukin-17A gene polymorphisms and susceptibility to systemic lupus erythematosus in Egyptian children and adolescents: a multi-centre study.
Lupus - 1 Jun 2020
Elkoumi Mohamed A, Allah Mayy An, Mohamed Faisal Y, Boraey Naglaa F, Abdellatif Sawsan H, Shehab Mohamed Mm, Sherif Ahmed H, Akeel Nagwa E, Saleh Rabab M, Elshreif Anas M, Abdelrahman Hind M, Soliman Attia A, Emam Ahmed A, Youssef Manal Aa, Fahmy Dalia S, Sallam Mohammad M, Nawara Abdalla M, Elgohary Elsayed A, Ismael Ali, El-Kaffas Sameh Mh, Sobeih Alaa A, Ibrahim Lamya M, Ibrahim Mohamed Am, Abdou Adel M, Yousry Sherif M, Osman Sherif F, El-Deeb Fatma M, Elhewala Ahmed A, Hafez Sahbaa Fm, Waked Nevin M, Elbasyouni Hany Aa, Fouad Rania A, Zeidan Nancy Ms, Nashat Mohamed, Farghaly Mohsen Aa
Abstract excerpt
BACKGROUND: Recently, the interleukin-17A (IL-17A) gene has emerged as a potential candidate gene for autoimmune disorders, including systemic lupus erythematosus (SLE). OBJECTIVES: This study aimed to investigate whether IL-17A polymorphisms at rs2275913 G/A, rs8193036 C/T and rs3748067 C/T could be susceptibility markers for juvenile-onset SLE (JSLE) and lupus nephritis (LN) in Egyptian children and...