Effects of Air Pollution Exposure and the MUC5B rs35705950 Variant on Interstitial Lung Disease Risk in Patients With Rheumatoid Arthritis.

doi:10.1002/resp.70181

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Effects of Air Pollution Exposure and the MUC5B rs35705950 Variant on Interstitial Lung Disease Risk in Patients With Rheumatoid Arthritis.

Respirology (Carlton, Vic.) - 1 Apr 2026

Sesé Lucile, Annesi-Maesano Isabella, Juge Pierre Antoine, Mayer Sophie, Sigaux Johanna, Crestani Bruno, Semerano Luca, Dessimond Boris, Borie Raphael, Debray Marie-Pierre, Combe Bruno, Constantin Arnaud, Didier Morgane, Brillet Pierre Yves, Alari Anna, Uzunhan Yurdagul, Dieudé Philippe, Nunes Hilario

Abstract excerpt

BACKGROUND AND OBJECTIVE: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) and idiopathic pulmonary fibrosis share common risk factors, including the MUC5B promoter variant (rs35705950). We examined the contribution of air pollutants to ILD risk in an RA population and assessed the modifying effect of genetic susceptibility. METHODS: This study included patients with RA who had undergone chest...

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PMID: 41486088
DOI: 10.1002/resp.70181

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MUC5B

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