Article

Spatial transcriptome sequencing of FFPE tissues at cellular level

2020-10-14

Abstract excerpt

Formalin-fixed paraffin-embedded (FFPE) tissues are the most abundant archivable specimens in clinical tissue banks, but unfortunately incompatible with single-cell level whole transcriptome sequencing due to RNA degradation in storage and RNA damage in extraction. We developed an in-tissue barcoding approach namely DBiT-seq for spatially revolved whole transcriptome sequencing at cellular level, which required no...

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Literature Corpus work: 50c6ab42-4c70-5355-a1dd-0d852893b9b6
DOI: 10.1101/2020.10.13.338475

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