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Article

Basal cell adenoma with S100 protein-positive "stroma": a distinct triphasic salivary gland neoplasm characterized by CTNNB1 mutation.

Virchows Archiv : an international journal of pathology - 1 Feb 2026

Skálová Alena, Bradová Martina, Laco Jan, Vaněček Tomáš, Hájková Veronika, Martínek Petr, Grendár Marián, Querzoli Giulia, Leivo Ilmo, Michal Michal

Abstract excerpt

Basal cell adenoma (BCA) is a benign salivary neoplasm that exhibits a divergent spectrum of growth patterns, including cribriform, tubular, trabecular, membranous, and solid. A subset of BCAs is characterized by the presence of abundant S100 protein-positive stroma, which makes this variant unique and potentially represents a hybrid lesion or an entity intermediate between BCA and pleomorphic adenoma (PA). From...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40515848
DOI: 10.1007/s00428-025-04141-2
PMCID: PMC12916997

Genes

PLAG1
CTNNB1
HMGA2
SOX10
ACTA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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