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Whole Genome Sequencing and Metabolomic Profiling of Six Clinical Mycobacterium Tuberculosis Isolates Reveal Drug Resistance-Associated Features.

Current microbiology - 27 Dec 2025

Sahoo Ashutosh, Mohapatra Amit Kumar, Priyadarsini Haripriya, Pemmadi Raghuveer Varma, Das Anjan, Choedon Tenzin, Nikam Chaitali, Behera Rajendra Kumar, Masakapalli Shyam Kumar, Nanda Ranjan Kumar

Abstract excerpt

Drug-resistant tuberculosis (DR-TB), resulting from newly emerging strains of Mycobacterium tuberculosis (Mtb), and the World Health Organisation (WHO) included it as a top-priority antimicrobial-resistant pathogen. Whole genome sequence analysis (WGS) of clinical Mtb isolates could correlate to their drug resistance phenotype and may also reflect their metabolome. In this report, clinical Mtb isolates (S1, S4,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41454966
DOI: 10.1007/s00284-025-04677-1

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