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Article

JMML and RALD (Ras-associated autoimmune leukoproliferative disorder): common genetic etiology yet clinically distinct entities.

Blood - 30 Apr 2015

Calvo Katherine R, Price Susan, Braylan Raul C, Oliveira Joao Bosco, Lenardo Michael, Fleisher Thomas A, Rao V Koneti

Abstract excerpt

Ras-associated autoimmune leukoproliferative disorder (RALD) is a chronic, nonmalignant condition that presents with persistent monocytosis and is often associated with leukocytosis, lymphoproliferation, and autoimmune phenomena. RALD has clinical and laboratory features that overlap with those of juvenile myelomonocytic leukemia (JMML) and chronic myelomonocytic leukemia (CMML), including identical somatic...

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Source

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Identifiers

PMID: 25691160
DOI: 10.1182/blood-2014-11-567917
PMCID: PMC4424627

Genes

KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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