Article
Lipid-Related Polygenic Risk Score and Its Association With Plaque Rupture Versus Erosion.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2026
Hamana Tomoyo, Gaynor Brady J, Grogan Alyssa, Turoni-Glitz Anne, Kawakami Rika, Shiraki Tatsuya, Sekimoto Teruo, Tanaka Takamasa, Fujiyoshi Kazuhiro, Nakayama Takafumi, Adachi Yusuke, Williams Desiree, Diaz Keisha Medina, Mitchell Braxton D, Virmani Renu, Finn Aloke V
Abstract excerpt
BACKGROUND: Distinct plaque morphologies underlie the major causes of acute coronary syndrome and sudden cardiac death. We used polygenic risk scores (PRSs) for hypercholesterolemia and hypertriglyceridemia, 2 major risk factors for coronary artery disease (CAD), to evaluate the relative contributions of these risk factors to specific plaque morphologies, specifically plaque rupture and erosion. METHODS: DNA was...
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