Article
Metabolic-switch macrophage cyborgs reverse atherosclerosis by photoacoustic-directed on-demand phenotype delivery.
Materials horizons - 9 Feb 2026
Zeng Wei, Fang Weimin, Mao Yuhang, Huang Yalan, Lin Yan, Wu Leilei, Chen Anqi, Huang Zhengan, Sheng Yuanyuan, Lin Xiaoxuan, Ye Jiayu, Guo Yanbin, Wen Guanxi, Zeng Jian, Xu Jinfeng, Zhou Liqiang, Liu Yingying
Abstract excerpt
Pathological macrophage activation orchestrates atherosclerotic plaque progression through sustained inflammation, necrotic core expansion, and plaque destabilization, a process recalcitrant to current targeted therapies. We address this fundamental challenge by engineering a living macrophage-based theranostic cyborg (MφMB-Au) that integrates precision plaque homing with spatiotemporally controlled...
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