Article
K-mer-based approach for serodiagnostic antigen discovery in Chagas disease using unassembled sequencing reads.
PLoS neglected tropical diseases - 1 Dec 2025
Honorato Nathan Ravi Medeiros, de Almeida Laila Viana, Reis-Cunha João Luís, Fraga Vanêssa Gomes, Souza Daniel Menezes, Nunes Ramon Vieira, Ribeiro-Dias Fátima, Ayala Edward Valencia, Noble Jeffery A, Marques Alexandre Ferreira, Finn M G, Galvão Lúcia Maria da Cunha, Bartholomeu Daniella C
Abstract excerpt
Trypanosoma cruzi, the causative agent of Chagas disease (CD), exhibits remarkable genetic diversity, classified into six discrete typing units (DTUs), and one additional DTU, TcBat, primarily associated with bats. These DTUs are distributed differentially across CD-endemic regions, posing significant challenges for molecular and serological diagnosis, as test performance often varies geographically. Identifying...
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