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Article

Strain-specific genome evolution in Trypanosoma cruzi, the agent of Chagas disease.

PLoS pathogens - 1 Jan 2021

Wang Wei, Peng Duo, Baptista Rodrigo P, Li Yiran, Kissinger Jessica C, Tarleton Rick L

Abstract excerpt

The protozoan Trypanosoma cruzi almost invariably establishes life-long infections in humans and other mammals, despite the development of potent host immune responses that constrain parasite numbers. The consistent, decades-long persistence of T. cruzi in human hosts arises at least in part from the remarkable level of genetic diversity in multiple families of genes encoding the primary target antigens of...

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Identifiers

PMID: 33508020
DOI: 10.1371/journal.ppat.1009254
PMCID: PMC7872254

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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