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Article

Metastatic colorectal adenocarcinoma with APC and EGFR L858R co-mutations: a case report.

The oncologist - 5 Feb 2026

Cavalheiro Vitor Jodar, Sobral Filho Daniel Santos Rocha, de Oliveira Giulia Mazaro, da Fonseca Manuela Del Rio Navarrete, Travessini Gabriel, Soares Ibere Cauduro, de Castro Junior Gilberto, Sabbaga Jorge, Mak Milena Perez, Gehm Hoff Paulo Marcelo

Abstract excerpt

Mutations in the adenomatous polyposis coli (APC) gene are frequent in colorectal cancer (CRC), whereas epidermal growth factor receptor (EGFR) mutations, particularly the L858R variant, are exceedingly rare. Their coexistence in CRC is rare and poorly described in the literature and poses diagnostic and therapeutic challenges. We describe a 69-year-old man with a history of resected CRC who presented with a lung...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41423794
DOI: 10.1093/oncolo/oyaf421
PMCID: PMC12923143

Genes

APC
EGFR
TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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