Association of apolipoprotein A1 (rs 5069) genotyping with 25-hydroxyvitamin D deficiency and insulin resistance as a metabolic and genetic difference in obesity and type 2 diabetes mellitus.

doi:10.1007/s00394-026-03938-4

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Association of apolipoprotein A1 (rs 5069) genotyping with 25-hydroxyvitamin D deficiency and insulin resistance as a metabolic and genetic difference in obesity and type 2 diabetes mellitus.

European journal of nutrition - 24 Mar 2026

Usama Nagla, Ahmed Amr E, Mekheimer Salma, Elhadidy Khaled, Awadein Mohamed, Farid Mahmoud

Abstract excerpt

BACKGROUND: Obesity and type 2 diabetes mellitus (T2DM) are significant issues for public health, frequently occurring together with vitamin D deficiency and metabolic diseases. This study aimed to investigate whether the APOA1 single nucleotide polymorphism rs5069 is associated with 25-hydroxyvitamin D (25[OH]D) deficiency and insulin-resistance–related traits in Egyptian adults. METHODS: In this cross-sectional...

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PMID: 41874699
DOI: 10.1007/s00394-026-03938-4
PMCID: PMC13013381

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APOA1

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