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Article

The interplay of APOE and APOA1 gene polymorphisms modulates the risk of type 2 diabetes mellitus in an obese population: a case-control study".

European journal of medical research - 27 Jan 2026

Usama Nagla, Ahmed Amr E, Mekheimer Salma, Elhadidy Khaled, Farid Mahmoud

Abstract excerpt

BACKGROUND: Genetic factors play an important role in metabolic disease susceptibility. Apolipoproteins E (APOE) and A1 (APOA1) are key regulators of lipid metabolism and have been individually associated with dyslipidemia and type 2 diabetes mellitus (T2DM). OBJECTIVE: This study aimed to examine the individual and combined associations of APOE (rs429358, rs7412) and APOA1 (rs5069) gene polymorphisms with...

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Source

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Identifiers

PMID: 41588446
DOI: 10.1186/s40001-025-03829-0
PMCID: PMC12849122

Genes

APOA1
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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