Article

A single PA-X mutation in bovine-origin H5N1 influenza virus reduces pathogenicity in mice

2026-05-10

Abstract excerpt

<h4>ABSTRACT</h4> Dairy cows have emerged as a reservoir for human infection with highly pathogenic avian influenza (HPAI) H5N1. At the bovine–human interface, H5N1 strains may acquire adaptive mutations that influence their zoonotic potential. Sequence analysis identified a K142E substitution (bovine to human) in the PA and PA-X proteins, with the potential to affect both polymerase activity and host shutoff. He...

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Literature Corpus work: 91126c82-9092-50f5-b562-a9731a5cad0e
DOI: 10.64898/2026.05.09.724031

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