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Duplicated zebrafish (Danio rerio) inositol phosphatases inpp5ka and inpp5kb diverged in expression pattern and function.

Development genes and evolution - 1 Jun 2023

Shukla Dhyanam, Gural Brian M, Cauley Edmund S, Battula Namarata, Mowla Shorbon, Karas Brittany F, Roberts Llion E, Cavallo Luca, Turkalj Luka, Moody Sally A, Swan Laura E, Manzini M Chiara

Abstract excerpt

One hurdle in the development of zebrafish models of human disease is the presence of multiple zebrafish orthologs resulting from whole genome duplication in teleosts. Mutations in inositol polyphosphate 5-phosphatase K (INPP5K) lead to a syndrome characterized by variable presentation of intellectual disability, brain abnormalities, cataracts, muscle disease, and short stature. INPP5K is a phosphatase acting at...

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PMID: 37184573
DOI: 10.1007/s00427-023-00703-z
PMCID: PMC10239392

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Duplicated zebrafish (Danio rerio) inositol phosphatases inpp5ka and inpp5kb diverged in expression pattern and function.PMID 37184573Read ↗

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