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Article

Extracellular adenosine deamination primes tip organizer development in Dictyostelium.

eLife - 17 Dec 2025

Hathi Pavani, Ramamurthy Baskar

Abstract excerpt

Ammonia is a morphogen in Dictyostelium and is known to arise from the catabolism of proteins and RNA. However, we show that extracellular adenosine deamination catalysed by 'adenosine deaminase-related growth factor' (ADGF) is a major source of ammonia and demonstrate a direct role of ammonia in tip organizer development. The tip formed during early development in Dictyostelium functions analogously to the...

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Identifiers

PMID: 41406008
DOI: 10.7554/eLife.104855
PMCID: PMC12711200

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