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Article

Ammonia promotes accumulation of intracellular cAMP in differentiating amoebae of Dictyostelium discoideum.

Development (Cambridge, England) - 1 Jul 1990

Riley B B, Barclay S L

Abstract excerpt

We used sporogenous mutants of Dictyostelium discoideum to investigate the mechanism(s) by which exogenous NH4Cl and high ambient pH promote spore formation during in vitro differentiation. The level of NH4Cl required to optimize spore formation is correlated inversely with pH, indicating that NH3 rather than NH4+ is the active species. The spore-promoting activity of high ambient pH (without exogenous NH4Cl) was...

Topics

Ammonia
Cell Differentiation
Cyclic AMP
Dictyostelium
Hydrogen-Ion Concentration
Mutation
Spores

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2169391
DOI: 10.1242/dev.109.3.715

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2169391-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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