Hidradenitis Suppurativa and Smoking, Obesity, Psoriasis, Inflammatory Bowel Disease, and Systemic Sclerosis: Results From A 2-Sample Mendelian Randomization Study.

doi:10.1001/jamadermatol.2025.5010

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Article

Hidradenitis Suppurativa and Smoking, Obesity, Psoriasis, Inflammatory Bowel Disease, and Systemic Sclerosis: Results From A 2-Sample Mendelian Randomization Study.

JAMA dermatology - 1 Feb 2026

Kjærsgaard Andersen Rune, Riis Peter Theut, Zachariae Claus, Thomsen Simon Francis, Quin Liam, Dinh Khoa Manh, Banasik Karina, Brunak Søren, Hansen Thomas, Hjalgrim Henrik, Sørensen Erik, Mikkelsen Christina, Ullum Henrik, Nyegaard Mette, Bruun Mie Topholm, Erikstrup Christian, Ostrowski Sisse Rye, Eidsmo Liv, Lindhardt Saunte Ditte Marie, Pedersen Ole Birger Vesterager, Jemec Gregor Borut Ernst

Abstract excerpt

Importance: Smoking and obesity are associated with risk of hidradenitis suppurativa, and both are considered important environmental risk factors. However, a causal relationship remains unproven. Objective: To primarily investigate the relationship between body mass index (BMI, calculated as weight in kilograms divided by height in meters squared) and smoking and HS, and secondarily to investigate potential...

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PMID: 41405899
DOI: 10.1001/jamadermatol.2025.5010
PMCID: PMC12712827

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