Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiomics analyses prioritize disease genes and pathways in hidradenitis suppurativa.

The Journal of investigative dermatology - 1 Jul 2026

Peacker Bryan L, Ly Liana, Hwang Jonathan C, Gravel-Pucillo Kai, Zheng Christy, Wheless Lee E, Ferolito Brian R, Cho Kelly, Gaziano John Michael, Pereira Alexandre C, Hartman Rebecca I

Abstract excerpt

Hidradenitis suppurativa is a chronic inflammatory skin condition associated with an increased risk of all-cause mortality. Although it is known to be influenced by genetic and environmental factors, the genetic contributors remain poorly characterized. We performed a large-scale meta-analysis involving patients from the Million Veteran Program, UK Biobank, and FinnGen, including a total of 3941 cases and...

Topics

Join the communities discussing this publication.

MPO gene
Genetic Predisposition to Disease
Genome-Wide Association Study
Hidradenitis Suppurativa
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Quantitative Trait Loci

Source

Identifiers

PMID: 41548865
DOI: 10.1016/j.jid.2025.12.025

Genes

KLF5
MPO
PSMA4
SMPD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiomics analyses prioritize disease genes and pathways in hidradenitis suppurativa.PMID 41548865Read ↗

PSMA4 as a Druggable Target in Hidradenitis Suppurativa: Evidence From Mendelian Randomization and Single-Cell Transcriptomics.Semantic proximity Read ↗

Integrated Proteogenomics and Single-Cell Transcriptomics Prioritize Putative Protective Plasma Proteins for Hidradenitis Suppurativa.Semantic proximity Read ↗

Leveraging genotypes and phenotypes to implement precision medicine in hidradenitis suppurativa management.Semantic proximity Read ↗

A Hidradenitis Suppurativa molecular disease signature derived from patient samples by high-throughput RNA sequencing and re-analysis of previously reported transcriptomic data setsSemantic proximity Read ↗

Integrative systems biology framework discovers common gene regulatory signatures in mechanistically distinct inflammatory skin diseasesSemantic proximity Read ↗

Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic SignalingSemantic proximity Read ↗

Genomic loci and molecular genetic mechanisms for hidradenitis suppurativa.Semantic proximity Read ↗

Hidradenitis Suppurativa: A Perspective on Genetic Factors Involved in the DiseaseSemantic proximity Read ↗

High-throughput proteomics identifies inflammatory proteins associated with disease severity and genetic ancestry in patients with hidradenitis suppurativaSemantic proximity Read ↗

The Hidradenitis Suppurativa ‘Omics Database (HS-OmicsDB)Semantic proximity Read ↗

A phenotype-to-mechanism framework links phenome-wide comorbidity architecture to molecular mechanisms and therapeutic discovery in complex diseasesSemantic proximity Read ↗

Identification of Novel Genetic Risk Variants Associated with Hidradenitis Suppurativa in an Exome Sequencing Cohort of 92,455 Individuals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.