Article
The impact of schizophrenia genetic load and heavy cannabis use on the risk of psychotic disorder in the EU-GEI case-control and UK Biobank studies.
Psychological medicine - 1 Nov 2024
Austin-Zimmerman Isabelle, Spinazzola Edoardo, Quattrone Diego, Wu-Choi Beatrice, Trotta Giulia, Li Zhikun, Johnson Emma, Richards Alexander L, Freeman Tom P, Tripoli Giada, Gayer-Anderson Charlotte, Rodriguez Victoria, Jongsma Hannah E, Ferraro Laura, La Cascia Caterina, Tosato Sarah, Tarricone Ilaria, Berardi Domenico, Bonora Elena, Seri Marco, D'Andrea Giuseppe, Szöke Andrei, Arango Celso, Bobes Julio, Sanjuán Julio, Santos Jose Luis, Arrojo Manuel, Velthorst Eva, Bernardo Miguel, Del-Ben Cristina Marta, Rossi Menezes Paulo, Selten Jean-Paul, Jones Peter B, Kirkbride James B, Rutten Bart P F, Tortelli Andrea, Llorca Pierre-Michel, de Haan Lieuwe, Stilo Simona, La Barbera Daniele, Lasalvia Antonio, Schurnhoff Franck, Pignon Baptiste, van Os Jim, Lynskey Michael, Morgan Craig, O' Donovan Michael, Lewis Cathryn M, Sham Pak C, Murray Robin M, Vassos Evangelos, Di Forti Marta
Abstract excerpt
BACKGROUND: The association between cannabis and psychosis is established, but the role of underlying genetics is unclear. We used data from the EU-GEI case-control study and UK Biobank to examine the independent and combined effect of heavy cannabis use and schizophrenia polygenic risk score (PRS) on risk for psychosis. METHODS: Genome-wide association study summary statistics from the Psychiatric Genomics...
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