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Assessing the impact of MSH3 and MSH6 polymorphisms on lung cancer risk in North Indian patients undergoing platinum chemotherapy through molecular dynamics simulation.

Scientific reports - 13 Jul 2024

Singh Sidhartha, Singh Navneet, Gupta Parth Sarthi Sen, Panda Saroj Kumar, Dhamija Isha, Nathiya Deepak, Kumar Sandeep, Sharma Siddharth

Abstract excerpt

The present study investigated the relationship between MSH3 and MSH6 genes in lung cancer patients. Genotyping of lung cancer patients and healthy controls was performed. Odds ratio values were calculated and survival analysis performed. Patients with mutant genotype (TT) for MSH6 polymorphism have 1.5-fold risk for the development of lung cancer (p = 0.03). For non-smokers, the mutant-type genotype had a...

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Identifiers

PMID: 39003369
DOI: 10.1038/s41598-024-67090-x
PMCID: PMC11246474

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