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Article

Skin Cancer Predisposition Genes, Full-Body Skin Examinations, Familial Disclosure, and Genetic Testing Among High-Risk Individuals.

International journal of dermatology - 1 Jul 2026

Freeman Jincong Q, Matsui Yu, Zhao Fangyuan, Olopade Olufunmilayo I, Huo Dezheng

Abstract excerpt

BACKGROUND: There is a lack of knowledge in full-body skin examinations (FBSEs) in the context of pathogenic or likely pathogenic variants (PV/LPV) in skin cancer predisposition genes (CPGs). This study assessed the association between carrier status of PV/LPV in skin CPGs and FBSEs and described the patterns of family letter receipt, familial disclosure, and cascade testing among high-risk individuals. METHODS:...

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Aged
Disclosure
Genetic Counseling
Genetic Predisposition to Disease
Genetic Testing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Physical Examination

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Identifiers

PMID: 41373161
DOI: 10.1111/ijd.70206
PMCID: PMC12818384

Genes

ATM
BRIP1
CDKN2A
CHEK2
PALB2
PTEN
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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