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Article

Genetics-mediated regulation of intestinal gene expression on microbiome contributes to human disease heritability.

Molecular systems biology - 1 Mar 2026

Wang Haochuan, Li Chengyu, Hu Zhen, Feng Haonan, Chen Luowei, Ding Ke, Nan Jiuhong, Wu Yuhan, Sheng Jinghao, Xiong Xushen

Abstract excerpt

The gut microbiome plays fundamental roles in physiological and pathological processes, yet its interaction with host gene expression and contribution to disease remain underexplored. Here, we integrate the genetic regulatory maps of 116 microbial genera with gene expression quantitative trait loci (eQTLs) and DNA methylation QTLs (mQTLs) in three intestinal tissues to dissect host-microbiome interaction. We...

Topics

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DNA Methylation
Gastrointestinal Microbiome
Gene Expression Regulation
Gene Regulatory Networks
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

Host Microbial Interactions

Quantitative Trait Loci

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Identifiers

PMID: 41350437
DOI: 10.1038/s44320-025-00173-7
PMCID: PMC12953866

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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