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Article

ABCB1 and ABCC10 polymorphisms predict sensitivity to first- and third-generation EGFR-TKIs in EGFR-mutant NSCLC.

Investigational new drugs - 1 Dec 2025

Toda-Shiraga Sanae, Uemura Takehiro, Kakihara Akihito, Hashiba Fumitaka, Tanaka Tatsuya, Ito Toshiyasu, Onuki Tomohiro, Ito Keima, Mori Yuta, Fukumitsu Kensuke, Fukuda Satoshi, Kanemitsu Yoshihiro, Tajiri Tomoko, Ohkubo Hirotsugu, Maeno Ken, Niimi Akio, Oguri Tetsuya

Abstract excerpt

This study investigated the association between ATP-binding cassette (ABC) transporter gene polymorphisms and Epidermal Growth Factor Receptor (EGFR)- Tyrosine kinase inhibitor (TKI) sensitivity in non-small cell lung cancer (NSCLC). Our goal was to determine if these genetic variations could serve as valuable biomarkers for predicting treatment efficacy. We examined the associations between ABC transporter mRNA...

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Source

Identifiers

PMID: 41343113
DOI: 10.1007/s10637-025-01594-9

Genes

EGFR
ABCB1
ABCC10
ABCC11
ABCG2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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