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Article

Acquisition of ampliconic sequences marks a selfish mouse t-haplotype.

Nature communications - 1 Dec 2025

Swanepoel Callie M, Wang Gaojianyong, Zhang Lucy, Brändl Björn, Bauer Hermann, Tsaytler Pavel, Müller Franz-Josef, Herrmann Bernhard G, Mueller Jacob L

Abstract excerpt

Mendelian genetics posits equal transmission of alleles, but selfish alleles can bias the transmission of large genomic regions or entire chromosomes. One long-standing question is how transmission bias evolves to encompass large genomic regions. Mus musculus (house mouse) t-haplotypes exhibit up to 99% transmission bias from heterozygous males and harbor selfish alleles genetically linked to large inversions...

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Identifiers

PMID: 41326354
DOI: 10.1038/s41467-025-66616-9
PMCID: PMC12764527

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